Detailed information of TA system TA277917

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 69603..70016
• Replicon: plasmid unnamed4
• Accession: NZ_CP122805
• Organism: Escherichia coli strain ETEC1734

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: QDX84_RS27380
• Protein ID: WP_096937776.1
• Coordinates: 69891..70016 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	69603..69814 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QDX84_RS27345 (65888)	65888..66322	+	435	WP_000845915.1	conjugation system SOS inhibitor PsiB	-
QDX84_RS27350 (66319)	66319..67075	+	757	Protein_68	plasmid SOS inhibition protein A	-
QDX84_RS27355 (67157)	67157..67582	+	426	WP_000422741.1	transposase	-
QDX84_RS27360 (67579)	67579..67929	+	351	WP_000624722.1	IS66 family insertion sequence element accessory protein TnpB	-
QDX84_RS27365 (67960)	67960..69573	+	1614	WP_282835484.1	IS66-like element ISEc23 family transposase	-
QDX84_RS27370 (69560)	69560..69778	-	219	WP_282835486.1	hypothetical protein	-
- (69747)	69747..69812	+	66	NuclAT_1	-	-
- (69747)	69747..69812	-	66	NuclAT_0	-	-
- (69600)	69600..69814	+	215	NuclAT_0	-	-
- (69600)	69600..69814	+	215	NuclAT_0	-	-
- (69600)	69600..69814	+	215	NuclAT_0	-	-
- (69600)	69600..69814	+	215	NuclAT_0	-	-
- (69603)	69603..69814	-	212	NuclAT_0	-	Antitoxin
QDX84_RS27375 (69800)	69800..69949	+	150	Protein_73	plasmid maintenance protein Mok	-
QDX84_RS27380 (69891)	69891..70016	+	126	WP_096937776.1	type I toxin-antitoxin system Hok family toxin	Toxin
QDX84_RS27385 (70361)	70361..71932	-	1572	WP_000381443.1	IS66 family transposase	-
QDX84_RS27390 (71952)	71952..72299	-	348	WP_000624618.1	IS66 family insertion sequence element accessory protein TnpB	-
QDX84_RS27395 (72299)	72299..72949	-	651	WP_000993956.1	IS66-like element accessory protein TnpA	-
QDX84_RS27400 (73035)	73035..73296	-	262	Protein_78	hypothetical protein	-
QDX84_RS27405 (73363)	73363..73539	+	177	Protein_79	DUF932 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4806.72 Da
• Isoelectric Point: 8.4890

>T277917 WP_096937776.1 NZ_CP122805:69891-70016 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGYREVAAFMAYESGK

Nucleotide

• Length: 126 bp

Antitoxin

Nucleotide

• Length: 212 bp

>AT277917 NZ_CP122805:c69814-69603 [Escherichia coli]
ATGTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCTTTCTGCCACACA
ACACGGCAACAAACCACCTTCACGTCATGAGGCAGAAAGCCTCAAGCGCCGGGCACATCATAGCCCATATACCTGCACGC
TGACCACACTCACTTTCCCTGAAAATAATCTGGTCGTTCAGCCAGTTCACGG

Structures

Antitoxin