Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 34655..34919 Replicon plasmid unnamed3
Accession NZ_CP122804
Organism Escherichia coli strain ETEC1734

Toxin (Protein)


Gene name pndA Uniprot ID U9Y6M3
Locus tag QDX84_RS26720 Protein ID WP_001331364.1
Coordinates 34767..34919 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 34655..34712 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX84_RS26705 (29895) 29895..32185 - 2291 Protein_40 F-type conjugative transfer protein TrbC -
QDX84_RS26710 (32178) 32178..33248 - 1071 WP_000151583.1 IncI1-type conjugal transfer protein TrbB -
QDX84_RS26715 (33267) 33267..34475 - 1209 WP_000121273.1 IncI1-type conjugal transfer protein TrbA -
- (34655) 34655..34712 - 58 NuclAT_0 - Antitoxin
- (34655) 34655..34712 - 58 NuclAT_0 - Antitoxin
- (34655) 34655..34712 - 58 NuclAT_0 - Antitoxin
- (34655) 34655..34712 - 58 NuclAT_0 - Antitoxin
QDX84_RS26720 (34767) 34767..34919 + 153 WP_001331364.1 Hok/Gef family protein Toxin
QDX84_RS26725 (34991) 34991..35242 - 252 WP_001291964.1 hypothetical protein -
QDX84_RS26730 (35328) 35328..36899 - 1572 WP_000381443.1 IS66 family transposase -
QDX84_RS26735 (36919) 36919..37266 - 348 WP_000624618.1 IS66 family insertion sequence element accessory protein TnpB -
QDX84_RS26740 (37266) 37266..37916 - 651 WP_000993956.1 IS66-like element accessory protein TnpA -
QDX84_RS26745 (38254) 38254..38787 - 534 WP_001372168.1 transcription termination/antitermination NusG family protein -
QDX84_RS26750 (39229) 39229..39516 - 288 WP_000074849.1 conjugal transfer protein TraA -
QDX84_RS26755 (39434) 39434..39664 - 231 WP_228772074.1 ash family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aadA5 / sul2 - 1..79114 79114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-46)


Sequences


Toxin        


Download         Length: 51 a.a.        Molecular weight: 5775.13 Da        Isoelectric Point: 8.7948

>T277910 WP_001331364.1 NZ_CP122804:34767-34919 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp


Antitoxin


Download         Length: 58 bp

>AT277910 NZ_CP122804:c34712-34655 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A5W9M382


Antitoxin

Download structure file

References