Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4151007..4151548 Replicon chromosome
Accession NZ_CP122801
Organism Escherichia coli strain ETEC1734

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag QDX84_RS21055 Protein ID WP_000615983.1
Coordinates 4151270..4151548 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag QDX84_RS21050 Protein ID WP_000729703.1
Coordinates 4151007..4151267 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX84_RS21030 (4146682) 4146682..4147467 - 786 WP_000207587.1 putative lateral flagellar export/assembly protein LafU -
QDX84_RS21035 (4147439) 4147439..4149151 + 1713 Protein_4119 flagellar biosynthesis protein FlhA -
QDX84_RS21040 (4149375) 4149375..4149872 - 498 Protein_4120 REP-associated tyrosine transposase RayT -
QDX84_RS21045 (4150048) 4150048..4150797 - 750 WP_024192679.1 C40 family peptidase -
QDX84_RS21050 (4151007) 4151007..4151267 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QDX84_RS21055 (4151270) 4151270..4151548 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QDX84_RS21060 (4151704) 4151704..4152444 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QDX84_RS21065 (4152415) 4152415..4153182 - 768 WP_000333380.1 class II glutamine amidotransferase -
QDX84_RS21070 (4153388) 4153388..4153966 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 4143849..4160089 16240


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T277907 WP_000615983.1 NZ_CP122801:4151270-4151548 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT277907 WP_000729703.1 NZ_CP122801:4151007-4151267 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References