Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 761723..762416 Replicon chromosome
Accession NZ_CP122801
Organism Escherichia coli strain ETEC1734

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QDX84_RS03705 Protein ID WP_000415584.1
Coordinates 761723..762019 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QDX84_RS03710 Protein ID WP_000650107.1
Coordinates 762021..762416 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX84_RS03670 (756810) 756810..757124 - 315 WP_000958598.1 putative quinol monooxygenase -
QDX84_RS03675 (757155) 757155..757737 - 583 Protein_720 NADPH:quinone oxidoreductase MdaB -
QDX84_RS03680 (758056) 758056..758388 + 333 WP_000917684.1 DUF2645 family protein -
QDX84_RS03685 (758434) 758434..759783 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
QDX84_RS03690 (759780) 759780..760439 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
QDX84_RS03695 (760591) 760591..760983 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QDX84_RS03700 (761036) 761036..761518 + 483 WP_000183505.1 GyrI-like domain-containing protein -
QDX84_RS03705 (761723) 761723..762019 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QDX84_RS03710 (762021) 762021..762416 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QDX84_RS03715 (762549) 762549..764157 + 1609 Protein_728 ABC transporter substrate-binding protein -
QDX84_RS03720 (764295) 764295..766553 + 2259 WP_159135099.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T277895 WP_000415584.1 NZ_CP122801:761723-762019 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT277895 WP_000650107.1 NZ_CP122801:762021-762416 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References