Detailed information of TA system TA277889

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 56257..56683
• Replicon: plasmid unnamed3
• Accession: NZ_CP122771
• Organism: Escherichia coli strain ETEC1738

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: QDY55_RS29790
• Protein ID: WP_001372321.1
• Coordinates: 56558..56683 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	56257..56481 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QDY55_RS29755 (52383)	52383..52817	+	435	WP_042634413.1	conjugation system SOS inhibitor PsiB	-
QDY55_RS29760 (52814)	52814..53533	+	720	WP_023181057.1	plasmid SOS inhibition protein A	-
QDY55_RS29765 (53567)	53567..55138	-	1572	WP_000381442.1	IS66 family transposase	-
QDY55_RS29770 (55158)	55158..55505	-	348	WP_000624618.1	IS66 family insertion sequence element accessory protein TnpB	-
QDY55_RS29775 (55505)	55505..56155	-	651	WP_000993956.1	IS66-like element accessory protein TnpA	-
QDY55_RS29780 (56257)	56257..56445	-	189	WP_032084246.1	hypothetical protein	-
- (56414)	56414..56479	+	66	NuclAT_1	-	-
- (56414)	56414..56479	-	66	NuclAT_0	-	-
- (56257)	56257..56481	+	225	NuclAT_0	-	Antitoxin
- (56257)	56257..56481	+	225	NuclAT_0	-	Antitoxin
- (56257)	56257..56481	+	225	NuclAT_0	-	Antitoxin
- (56257)	56257..56481	+	225	NuclAT_0	-	Antitoxin
- (56257)	56257..56481	-	225	NuclAT_0	-	-
QDY55_RS29785 (56467)	56467..56616	+	150	Protein_70	plasmid maintenance protein Mok	-
QDY55_RS29790 (56558)	56558..56683	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
QDY55_RS29795 (57078)	57078..58745	-	1668	WP_052991863.1	group II intron reverse transcriptase/maturase	-
QDY55_RS29800 (59474)	59474..59647	-	174	Protein_73	hypothetical protein	-
QDY55_RS29805 (59717)	59717..59923	+	207	WP_000547968.1	hypothetical protein	-
QDY55_RS29810 (59948)	59948..60235	+	288	WP_000107535.1	hypothetical protein	-
QDY55_RS29815 (60353)	60353..61174	+	822	WP_001234469.1	DUF932 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T277889 WP_001372321.1 NZ_CP122771:56558-56683 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

Antitoxin

Nucleotide

• Length: 225 bp

>AT277889 NZ_CP122771:56257-56481 [Escherichia coli]
TCACATGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin