Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 690411..691210 Replicon chromosome
Accession NZ_CP122768
Organism Escherichia coli strain ETEC1738

Toxin (Protein)


Gene name yhaV Uniprot ID D3GWU5
Locus tag QDY55_RS03365 Protein ID WP_000347272.1
Coordinates 690411..690875 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDY55_RS03370 Protein ID WP_001307405.1
Coordinates 690875..691210 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY55_RS03335 (685412) 685412..685846 - 435 WP_000948837.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDY55_RS03340 (685864) 685864..686742 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QDY55_RS03345 (686732) 686732..687511 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDY55_RS03350 (687522) 687522..687995 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDY55_RS03355 (688018) 688018..689298 - 1281 WP_064226321.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDY55_RS03360 (689547) 689547..690356 + 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
QDY55_RS03365 (690411) 690411..690875 - 465 WP_000347272.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDY55_RS03370 (690875) 690875..691210 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDY55_RS03375 (691359) 691359..692930 - 1572 WP_064226322.1 galactarate dehydratase -
QDY55_RS03380 (693305) 693305..694639 + 1335 WP_064226323.1 galactarate/glucarate/glycerate transporter GarP -
QDY55_RS03385 (694655) 694655..695425 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17832.26 Da        Isoelectric Point: 9.6924

>T277862 WP_000347272.1 NZ_CP122768:c690875-690411 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEPH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277862 WP_001307405.1 NZ_CP122768:c691210-690875 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829KUD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References