Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3773839..3774533 Replicon chromosome
Accession NZ_CP122758
Organism Escherichia coli strain ETEC1739

Toxin (Protein)


Gene name yafO Uniprot ID S1EXB8
Locus tag QDW95_RS18655 Protein ID WP_001263493.1
Coordinates 3773839..3774237 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1FJN6
Locus tag QDW95_RS18660 Protein ID WP_000554757.1
Coordinates 3774240..3774533 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
- (3769499) 3769499..3769579 - 81 NuclAT_11 - -
- (3769499) 3769499..3769579 - 81 NuclAT_11 - -
- (3769499) 3769499..3769579 - 81 NuclAT_11 - -
- (3769499) 3769499..3769579 - 81 NuclAT_11 - -
QDW95_RS18625 (3768839) 3768839..3770083 - 1245 WP_000189541.1 esterase FrsA -
QDW95_RS18630 (3770175) 3770175..3770633 - 459 WP_001291990.1 xanthine phosphoribosyltransferase -
QDW95_RS18635 (3770894) 3770894..3772351 + 1458 WP_001293003.1 cytosol nonspecific dipeptidase -
QDW95_RS18640 (3772408) 3772408..3772929 - 522 Protein_3651 peptide chain release factor H -
QDW95_RS18645 (3772928) 3772928..3773131 - 204 Protein_3652 RtcB family protein -
QDW95_RS18650 (3773377) 3773377..3773829 - 453 WP_001059847.1 GNAT family N-acetyltransferase -
QDW95_RS18655 (3773839) 3773839..3774237 - 399 WP_001263493.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
QDW95_RS18660 (3774240) 3774240..3774533 - 294 WP_000554757.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
QDW95_RS18665 (3774585) 3774585..3775641 - 1057 Protein_3656 DNA polymerase IV -
QDW95_RS18670 (3775712) 3775712..3776497 - 786 WP_000207564.1 putative lateral flagellar export/assembly protein LafU -
QDW95_RS18675 (3776469) 3776469..3778181 + 1713 Protein_3658 flagellar biosynthesis protein FlhA -
QDW95_RS18680 (3778405) 3778405..3778902 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15472.83 Da        Isoelectric Point: 8.0949

>T277845 WP_001263493.1 NZ_CP122758:c3774237-3773839 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.81 Da        Isoelectric Point: 5.9050

>AT277845 WP_000554757.1 NZ_CP122758:c3774533-3774240 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1EXB8

Antitoxin

Source ID Structure
AlphaFold DB S1FJN6

References