Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1809087..1809589 Replicon chromosome
Accession NZ_CP122758
Organism Escherichia coli strain ETEC1739

Toxin (Protein)


Gene name yoeB Uniprot ID D3GZ85
Locus tag QDW95_RS08815 Protein ID WP_000767820.1
Coordinates 1809335..1809589 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QDW95_RS08810 Protein ID WP_001259255.1
Coordinates 1809087..1809338 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW95_RS08785 (1804264) 1804264..1805331 - 1068 WP_072668050.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QDW95_RS08790 (1805331) 1805331..1806401 - 1071 WP_000108928.1 histidinol-phosphate transaminase -
QDW95_RS08795 (1806398) 1806398..1807702 - 1305 WP_000009586.1 histidinol dehydrogenase -
QDW95_RS08800 (1807708) 1807708..1808607 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QDW95_RS08805 (1808753) 1808753..1808803 - 51 WP_001364200.1 his operon leader peptide -
QDW95_RS08810 (1809087) 1809087..1809338 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QDW95_RS08815 (1809335) 1809335..1809589 + 255 WP_000767820.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QDW95_RS08820 (1809672) 1809672..1810496 + 825 WP_000754756.1 SDR family oxidoreductase -
QDW95_RS08825 (1810542) 1810542..1811471 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
QDW95_RS08830 (1811686) 1811686..1811748 + 63 WP_010723108.1 membrane protein YoeI -
QDW95_RS08835 (1811738) 1811738..1813096 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QDW95_RS08840 (1813275) 1813275..1814333 + 1059 WP_000492324.1 thiosulfate utilization transporter TsuA/YeeE -
QDW95_RS08845 (1814347) 1814347..1814574 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10182.64 Da        Isoelectric Point: 8.0353

>T277837 WP_000767820.1 NZ_CP122758:1809335-1809589 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKIIELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT277837 WP_001259255.1 NZ_CP122758:1809087-1809338 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3GZ85

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References