Detailed information of TA system TA277819

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2550213..2550584
• Replicon: chromosome
• Accession: NZ_CP122727
• Organism: Escherichia coli strain ETEC1746

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: -
• Locus tag: QDW99_RS12510
• Protein ID: WP_032083637.1
• Coordinates: 2550213..2550407 (+)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2550406..2550584 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QDW99_RS12490 (2545315)	2545315..2545491	+	177	WP_000241145.1	YdaE family protein	-
QDW99_RS12495 (2545565)	2545565..2545840	+	276	WP_000632298.1	hypothetical protein	-
QDW99_RS12500 (2545942)	2545942..2549085	+	3144	WP_032083635.1	exodeoxyribonuclease VIII	-
QDW99_RS12505 (2549097)	2549097..2550149	+	1053	WP_032083636.1	RecT family recombinase	-
QDW99_RS12510 (2550213)	2550213..2550407	+	195	WP_032083637.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
- (2550406)	2550406..2550584	-	179	NuclAT_8	-	Antitoxin
- (2550406)	2550406..2550584	-	179	NuclAT_8	-	Antitoxin
- (2550406)	2550406..2550584	-	179	NuclAT_8	-	Antitoxin
- (2550406)	2550406..2550584	-	179	NuclAT_8	-	Antitoxin
QDW99_RS12515 (2550400)	2550400..2550588	+	189	WP_001602382.1	DUF1187 family protein	-
QDW99_RS12520 (2550688)	2550688..2550903	+	216	WP_000079604.1	excisionase XisR	-
QDW99_RS12525 (2550905)	2550905..2552140	+	1236	WP_072014650.1	site-specific integrase	-
QDW99_RS12530 (2552192)	2552192..2553127	+	936	WP_001157377.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
QDW99_RS12535 (2553256)	2553256..2554629	-	1374	WP_000123737.1	ATP-dependent RNA helicase DbpA	-
QDW99_RS12540 (2554659)	2554659..2554832	-	174	WP_001296046.1	protein YnaL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2510859..2559399	48540

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7107.02 Da
• Isoelectric Point: 9.5240

>T277819 WP_032083637.1 NZ_CP122727:2550213-2550407 [Escherichia coli]
MRYEKVKPYPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

Antitoxin

Nucleotide

• Length: 179 bp

>AT277819 NZ_CP122727:c2550584-2550406 [Escherichia coli]
GAAGATTGAAGTTTCTCGCAATTAAAATTTATAAGTTTTACTTTCTGCTCTCTGGAAACACCAGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCCGATTTGGTTAACTTTGTTGTTGAGTACCTTGTCCAGCTGGTAGGAGAACCTCCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Antitoxin