Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1840025..1840527 Replicon chromosome
Accession NZ_CP122727
Organism Escherichia coli strain ETEC1746

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag QDW99_RS08875 Protein ID WP_001471733.1
Coordinates 1840273..1840527 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QDW99_RS08870 Protein ID WP_001259255.1
Coordinates 1840025..1840276 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW99_RS08845 (1835203) 1835203..1836270 - 1068 WP_001374028.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QDW99_RS08850 (1836270) 1836270..1837340 - 1071 WP_001374029.1 histidinol-phosphate transaminase -
QDW99_RS08855 (1837337) 1837337..1838641 - 1305 WP_001748534.1 histidinol dehydrogenase -
QDW99_RS08860 (1838647) 1838647..1839546 - 900 WP_001374031.1 ATP phosphoribosyltransferase -
QDW99_RS08865 (1839692) 1839692..1839742 - 51 WP_001364200.1 his operon leader peptide -
QDW99_RS08870 (1840025) 1840025..1840276 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QDW99_RS08875 (1840273) 1840273..1840527 + 255 WP_001471733.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QDW99_RS08880 (1840610) 1840610..1841434 + 825 WP_000754737.1 SDR family oxidoreductase -
QDW99_RS08885 (1841480) 1841480..1842409 + 930 WP_001374016.1 LysR substrate-binding domain-containing protein -
QDW99_RS08890 (1842624) 1842624..1842686 + 63 WP_010723108.1 membrane protein YoeI -
QDW99_RS08895 (1842676) 1842676..1844034 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10195.64 Da        Isoelectric Point: 8.0353

>T277813 WP_001471733.1 NZ_CP122727:1840273-1840527 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDIRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT277813 WP_001259255.1 NZ_CP122727:1840025-1840276 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References