Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 754450..755143 Replicon chromosome
Accession NZ_CP122727
Organism Escherichia coli strain ETEC1746

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QDW99_RS03685 Protein ID WP_000415584.1
Coordinates 754450..754746 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QDW99_RS03690 Protein ID WP_000650107.1
Coordinates 754748..755143 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW99_RS03650 (750006) 750006..750170 + 165 Protein_716 DUF2645 domain-containing protein -
QDW99_RS03660 (750939) 750939..751115 + 177 Protein_718 DUF2645 domain-containing protein -
QDW99_RS03665 (751161) 751161..752510 - 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
QDW99_RS03670 (752507) 752507..753166 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
QDW99_RS03675 (753318) 753318..753710 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QDW99_RS03680 (753763) 753763..754245 + 483 WP_000183505.1 GyrI-like domain-containing protein -
QDW99_RS03685 (754450) 754450..754746 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QDW99_RS03690 (754748) 754748..755143 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QDW99_RS03695 (755276) 755276..756883 + 1608 WP_032083699.1 ABC transporter substrate-binding protein -
QDW99_RS03700 (757021) 757021..759279 + 2259 WP_001618856.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T277810 WP_000415584.1 NZ_CP122727:754450-754746 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT277810 WP_000650107.1 NZ_CP122727:754748-755143 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References