Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-agrB/- |
| Location | 109988..110346 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP122724 | ||
| Organism | Escherichia coli strain ETEC1747 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | QDW91_RS27165 | Protein ID | WP_151318007.1 |
| Coordinates | 109988..110089 (-) | Length | 34 a.a. |
Antitoxin (RNA)
| Gene name | agrB | ||
| Locus tag | - | ||
| Coordinates | 110198..110346 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QDW91_RS27130 (105156) | 105156..105977 | - | 822 | WP_042634481.1 | DUF932 domain-containing protein | - |
| QDW91_RS27135 (106083) | 106083..106379 | - | 297 | WP_021558926.1 | hypothetical protein | - |
| QDW91_RS27140 (106403) | 106403..106609 | - | 207 | WP_000547945.1 | hypothetical protein | - |
| QDW91_RS27145 (106679) | 106679..106999 | + | 321 | Protein_125 | hypothetical protein | - |
| QDW91_RS27150 (107025) | 107025..108596 | - | 1572 | WP_000381442.1 | IS66 family transposase | - |
| QDW91_RS27155 (108616) | 108616..108963 | - | 348 | WP_000624618.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| QDW91_RS27160 (108963) | 108963..109613 | - | 651 | WP_000993956.1 | IS66-like element accessory protein TnpA | - |
| QDW91_RS27165 (109988) | 109988..110089 | - | 102 | WP_151318007.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| QDW91_RS27170 (110055) | 110055..110132 | - | 78 | Protein_130 | DUF5431 family protein | - |
| - (110198) | 110198..110346 | - | 149 | NuclAT_0 | - | Antitoxin |
| - (110198) | 110198..110346 | - | 149 | NuclAT_0 | - | Antitoxin |
| - (110198) | 110198..110346 | - | 149 | NuclAT_0 | - | Antitoxin |
| - (110198) | 110198..110346 | - | 149 | NuclAT_0 | - | Antitoxin |
| QDW91_RS27175 (110322) | 110322..110840 | - | 519 | WP_001178554.1 | hypothetical protein | - |
| QDW91_RS27180 (110840) | 110840..111559 | - | 720 | WP_042634414.1 | plasmid SOS inhibition protein A | - |
| QDW91_RS27185 (111556) | 111556..111990 | - | 435 | WP_042634413.1 | conjugation system SOS inhibitor PsiB | - |
| QDW91_RS27190 (112045) | 112045..114003 | - | 1959 | WP_042634412.1 | ParB/RepB/Spo0J family partition protein | - |
| QDW91_RS27195 (114067) | 114067..114300 | - | 234 | WP_000005971.1 | DUF905 domain-containing protein | - |
| QDW91_RS27200 (114356) | 114356..114886 | - | 531 | WP_032214168.1 | single-stranded DNA-binding protein | - |
| QDW91_RS27205 (114912) | 114912..115118 | - | 207 | WP_000547945.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | estIa / hlyD / hlyB / hlyB / hlyA / hlyC | 1..130771 | 130771 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 34 a.a. Molecular weight: 3921.52 Da Isoelectric Point: 7.9707
>T277804 WP_151318007.1 NZ_CP122724:c110089-109988 [Escherichia coli]
MIFTYLTRKSLCEIRYRDGDREVAAFMAYESGK
MIFTYLTRKSLCEIRYRDGDREVAAFMAYESGK
Download Length: 102 bp
Antitoxin
Download Length: 149 bp
>AT277804 NZ_CP122724:c110346-110198 [Escherichia coli]
CAGGGTGCAGACATATGGGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGT
GTTGTGTGGCAGAAAGAAGATAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGCATCCCATATGTCT
CAGGGTGCAGACATATGGGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGT
GTTGTGTGGCAGAAAGAAGATAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGCATCCCATATGTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
