Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1165918..1166645 Replicon chromosome
Accession NZ_CP122722
Organism Escherichia coli strain ETEC1747

Toxin (Protein)


Gene name higB Uniprot ID J7Q991
Locus tag QDW91_RS05780 Protein ID WP_000547564.1
Coordinates 1165918..1166229 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW91_RS05785 Protein ID WP_000126294.1
Coordinates 1166226..1166645 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW91_RS05750 (1161060) 1161060..1162769 + 1710 WP_001288134.1 formate hydrogenlyase subunit HycE -
QDW91_RS05755 (1162779) 1162779..1163321 + 543 WP_000493792.1 formate hydrogenlyase subunit HycF -
QDW91_RS05760 (1163321) 1163321..1164088 + 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
QDW91_RS05765 (1164085) 1164085..1164495 + 411 WP_001291921.1 formate hydrogenlyase assembly protein HycH -
QDW91_RS05770 (1164488) 1164488..1164958 + 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
QDW91_RS05775 (1164983) 1164983..1165744 + 762 WP_001026446.1 hypothetical protein -
QDW91_RS05780 (1165918) 1165918..1166229 + 312 WP_000547564.1 type II toxin-antitoxin system HigB family toxin Toxin
QDW91_RS05785 (1166226) 1166226..1166645 + 420 WP_000126294.1 helix-turn-helix domain-containing protein Antitoxin
QDW91_RS05790 (1166759) 1166759..1168183 - 1425 WP_000110313.1 6-phospho-beta-glucosidase AscB -
QDW91_RS05795 (1168192) 1168192..1169649 - 1458 WP_001107856.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
QDW91_RS05800 (1169909) 1169909..1170919 + 1011 WP_001363554.1 DNA-binding transcriptional regulator AscG -
QDW91_RS05805 (1171068) 1171068..1171595 + 528 WP_001078777.1 electron transport protein HydN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12426.13 Da        Isoelectric Point: 9.7248

>T277783 WP_000547564.1 NZ_CP122722:1165918-1166229 [Escherichia coli]
MHIISKAPFEESARKYPNDALALQALYRVIKETDFSTPEEMRTAFPNLDNFRYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT277783 WP_000126294.1 NZ_CP122722:1166226-1166645 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A0FJG5

Antitoxin

Source ID Structure

References