Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 752843..753536 Replicon chromosome
Accession NZ_CP122722
Organism Escherichia coli strain ETEC1747

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QDW91_RS03705 Protein ID WP_000415584.1
Coordinates 752843..753139 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QDW91_RS03710 Protein ID WP_000650107.1
Coordinates 753141..753536 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW91_RS03675 (748518) 748518..748832 - 315 WP_000958598.1 putative quinol monooxygenase -
QDW91_RS03680 (748863) 748863..749444 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QDW91_RS03685 (749554) 749554..750903 - 1350 WP_000673406.1 quorum sensing histidine kinase QseC -
QDW91_RS03690 (750900) 750900..751559 - 660 WP_001221491.1 quorum sensing response regulator transcription factor QseB -
QDW91_RS03695 (751711) 751711..752103 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QDW91_RS03700 (752156) 752156..752638 + 483 WP_000183498.1 GyrI-like domain-containing protein -
QDW91_RS03705 (752843) 752843..753139 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QDW91_RS03710 (753141) 753141..753536 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QDW91_RS03715 (753669) 753669..755276 + 1608 WP_001324265.1 ABC transporter substrate-binding protein -
QDW91_RS03720 (755414) 755414..757672 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 741115..753536 12421


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T277779 WP_000415584.1 NZ_CP122722:752843-753139 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT277779 WP_000650107.1 NZ_CP122722:753141-753536 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References