Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 621430..622229 Replicon chromosome
Accession NZ_CP122722
Organism Escherichia coli strain ETEC1747

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QDW91_RS03060 Protein ID WP_000347251.1
Coordinates 621430..621894 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDW91_RS03065 Protein ID WP_001307405.1
Coordinates 621894..622229 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW91_RS03030 (616431) 616431..616865 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDW91_RS03035 (616883) 616883..617761 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QDW91_RS03040 (617751) 617751..618530 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDW91_RS03045 (618541) 618541..619014 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDW91_RS03050 (619037) 619037..620317 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDW91_RS03055 (620566) 620566..621375 + 810 WP_000072192.1 aga operon transcriptional regulator AgaR -
QDW91_RS03060 (621430) 621430..621894 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDW91_RS03065 (621894) 621894..622229 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDW91_RS03070 (622378) 622378..623949 - 1572 WP_001273761.1 galactarate dehydratase -
QDW91_RS03075 (624324) 624324..625658 + 1335 WP_000599653.1 galactarate/glucarate/glycerate transporter GarP -
QDW91_RS03080 (625674) 625674..626444 + 771 WP_236499945.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T277778 WP_000347251.1 NZ_CP122722:c621894-621430 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277778 WP_001307405.1 NZ_CP122722:c622229-621894 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References