Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4878707..4879309 Replicon chromosome
Accession NZ_CP122719
Organism Escherichia coli strain ETEC1748

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QDW92_RS23975 Protein ID WP_000897305.1
Coordinates 4878998..4879309 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW92_RS23970 Protein ID WP_000356395.1
Coordinates 4878707..4878997 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW92_RS23935 (4874331) 4874331..4875233 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QDW92_RS23940 (4875230) 4875230..4875865 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QDW92_RS23945 (4875862) 4875862..4876791 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QDW92_RS23950 (4876973) 4876973..4877215 - 243 WP_001306649.1 protein YiiF -
QDW92_RS23955 (4877434) 4877434..4877652 - 219 WP_001295676.1 CopG family transcriptional regulator -
QDW92_RS23960 (4878071) 4878071..4878349 - 279 WP_001306650.1 hypothetical protein -
QDW92_RS23965 (4878401) 4878401..4878622 - 222 WP_001550354.1 hypothetical protein -
QDW92_RS23970 (4878707) 4878707..4878997 - 291 WP_000356395.1 NadS family protein Antitoxin
QDW92_RS23975 (4878998) 4878998..4879309 - 312 WP_000897305.1 hypothetical protein Toxin
QDW92_RS23980 (4879538) 4879538..4880446 + 909 WP_001306651.1 alpha/beta hydrolase -
QDW92_RS23985 (4880615) 4880615..4881529 - 915 WP_225102955.1 transposase -
QDW92_RS23990 (4881542) 4881542..4882429 - 888 Protein_4690 hypothetical protein -
QDW92_RS23995 (4882845) 4882845..4883786 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QDW92_RS24000 (4883831) 4883831..4884268 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T277774 WP_000897305.1 NZ_CP122719:c4879309-4878998 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT277774 WP_000356395.1 NZ_CP122719:c4878997-4878707 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References