Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1151632..1152359 Replicon chromosome
Accession NZ_CP122719
Organism Escherichia coli strain ETEC1748

Toxin (Protein)


Gene name higB Uniprot ID V0YLE2
Locus tag QDW92_RS05570 Protein ID WP_000547555.1
Coordinates 1151632..1151943 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW92_RS05575 Protein ID WP_000126294.1
Coordinates 1151940..1152359 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW92_RS05545 (1147567) 1147567..1149276 + 1710 WP_063086195.1 formate hydrogenlyase subunit HycE -
QDW92_RS05550 (1149286) 1149286..1149828 + 543 WP_000493785.1 formate hydrogenlyase subunit HycF -
QDW92_RS05555 (1149828) 1149828..1150595 + 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
QDW92_RS05560 (1150592) 1150592..1151002 + 411 WP_001291921.1 formate hydrogenlyase assembly protein HycH -
QDW92_RS05565 (1150995) 1150995..1151465 + 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
QDW92_RS05570 (1151632) 1151632..1151943 + 312 WP_000547555.1 type II toxin-antitoxin system HigB family toxin Toxin
QDW92_RS05575 (1151940) 1151940..1152359 + 420 WP_000126294.1 helix-turn-helix domain-containing protein Antitoxin
QDW92_RS05580 (1152438) 1152438..1153862 - 1425 WP_063086210.1 6-phospho-beta-glucosidase AscB -
QDW92_RS05585 (1153871) 1153871..1155328 - 1458 WP_001107888.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
QDW92_RS05590 (1155588) 1155588..1156598 + 1011 WP_029130985.1 DNA-binding transcriptional regulator AscG -
QDW92_RS05595 (1156747) 1156747..1157274 + 528 WP_001078777.1 electron transport protein HydN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12439.18 Da        Isoelectric Point: 9.5146

>T277754 WP_000547555.1 NZ_CP122719:1151632-1151943 [Escherichia coli]
MHIISKAPFEECARKYPNDALALHSLYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT277754 WP_000126294.1 NZ_CP122719:1151940-1152359 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0YLE2

Antitoxin

Source ID Structure

References