Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4183889..4184430 Replicon chromosome
Accession NZ_CP122712
Organism Escherichia coli strain ETEC1749

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag QDX02_RS21255 Protein ID WP_000615976.1
Coordinates 4184152..4184430 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag QDX02_RS21250 Protein ID WP_000729704.1
Coordinates 4183889..4184149 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX02_RS21230 (4179564) 4179564..4180349 - 786 WP_000207587.1 putative lateral flagellar export/assembly protein LafU -
QDX02_RS21235 (4180321) 4180321..4182033 + 1713 Protein_4163 flagellar biosynthesis protein FlhA -
QDX02_RS21240 (4182257) 4182257..4182754 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
QDX02_RS21245 (4182930) 4182930..4183703 - 774 WP_015675129.1 C40 family peptidase -
QDX02_RS21250 (4183889) 4183889..4184149 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QDX02_RS21255 (4184152) 4184152..4184430 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QDX02_RS21260 (4184586) 4184586..4185326 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QDX02_RS21265 (4185297) 4185297..4186064 - 768 WP_000333379.1 class II glutamine amidotransferase -
QDX02_RS21270 (4186270) 4186270..4186848 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T277740 WP_000615976.1 NZ_CP122712:4184152-4184430 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT277740 WP_000729704.1 NZ_CP122712:4183889-4184149 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References