Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1155522..1156215 Replicon chromosome
Accession NZ_CP122712
Organism Escherichia coli strain ETEC1749

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QDX02_RS05605 Protein ID WP_000415584.1
Coordinates 1155919..1156215 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QDX02_RS05600 Protein ID WP_000650107.1
Coordinates 1155522..1155917 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX02_RS05590 (1151386) 1151386..1153644 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
QDX02_RS05595 (1153782) 1153782..1155389 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
QDX02_RS05600 (1155522) 1155522..1155917 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QDX02_RS05605 (1155919) 1155919..1156215 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QDX02_RS05610 (1156420) 1156420..1156902 - 483 WP_000183505.1 GyrI-like domain-containing protein -
QDX02_RS05615 (1156955) 1156955..1157347 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QDX02_RS05620 (1157499) 1157499..1158158 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
QDX02_RS05625 (1158155) 1158155..1159504 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
QDX02_RS05630 (1159550) 1159550..1159882 - 333 WP_000917684.1 DUF2645 family protein -
QDX02_RS05635 (1160201) 1160201..1160782 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QDX02_RS05640 (1160813) 1160813..1161127 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T277721 WP_000415584.1 NZ_CP122712:c1156215-1155919 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT277721 WP_000650107.1 NZ_CP122712:c1155917-1155522 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References