Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4890559..4891161 Replicon chromosome
Accession NZ_CP122685
Organism Escherichia coli strain ETEC4067

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QDX30_RS24070 Protein ID WP_000897305.1
Coordinates 4890850..4891161 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDX30_RS24065 Protein ID WP_000356395.1
Coordinates 4890559..4890849 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX30_RS24030 (4886183) 4886183..4887085 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QDX30_RS24035 (4887082) 4887082..4887717 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QDX30_RS24040 (4887714) 4887714..4888643 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QDX30_RS24045 (4888825) 4888825..4889067 - 243 WP_001306649.1 protein YiiF -
QDX30_RS24050 (4889286) 4889286..4889504 - 219 WP_001295676.1 CopG family transcriptional regulator -
QDX30_RS24055 (4889923) 4889923..4890201 - 279 WP_001306650.1 hypothetical protein -
QDX30_RS24060 (4890253) 4890253..4890474 - 222 WP_001550354.1 hypothetical protein -
QDX30_RS24065 (4890559) 4890559..4890849 - 291 WP_000356395.1 NadS family protein Antitoxin
QDX30_RS24070 (4890850) 4890850..4891161 - 312 WP_000897305.1 hypothetical protein Toxin
QDX30_RS24075 (4891390) 4891390..4892298 + 909 WP_001306651.1 alpha/beta hydrolase -
QDX30_RS24080 (4892467) 4892467..4893381 - 915 WP_225102955.1 transposase -
QDX30_RS24085 (4893394) 4893394..4894281 - 888 Protein_4708 hypothetical protein -
QDX30_RS24090 (4894697) 4894697..4895638 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QDX30_RS24095 (4895683) 4895683..4896120 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T277711 WP_000897305.1 NZ_CP122685:c4891161-4890850 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT277711 WP_000356395.1 NZ_CP122685:c4890849-4890559 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References