Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4775116..4775718 Replicon chromosome
Accession NZ_CP122681
Organism Escherichia coli strain ETEC4068

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QDW67_RS23275 Protein ID WP_000897305.1
Coordinates 4775407..4775718 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW67_RS23270 Protein ID WP_000356395.1
Coordinates 4775116..4775406 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW67_RS23235 (4770740) 4770740..4771642 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QDW67_RS23240 (4771639) 4771639..4772274 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QDW67_RS23245 (4772271) 4772271..4773200 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QDW67_RS23250 (4773382) 4773382..4773624 - 243 WP_001306649.1 protein YiiF -
QDW67_RS23255 (4773843) 4773843..4774061 - 219 WP_001295676.1 CopG family transcriptional regulator -
QDW67_RS23260 (4774480) 4774480..4774758 - 279 WP_001306650.1 hypothetical protein -
QDW67_RS23265 (4774810) 4774810..4775031 - 222 WP_001550354.1 hypothetical protein -
QDW67_RS23270 (4775116) 4775116..4775406 - 291 WP_000356395.1 NadS family protein Antitoxin
QDW67_RS23275 (4775407) 4775407..4775718 - 312 WP_000897305.1 hypothetical protein Toxin
QDW67_RS23280 (4775947) 4775947..4776855 + 909 WP_001306651.1 alpha/beta hydrolase -
QDW67_RS23285 (4777024) 4777024..4777938 - 915 WP_225102955.1 transposase -
QDW67_RS23290 (4777951) 4777951..4778838 - 888 Protein_4549 hypothetical protein -
QDW67_RS23295 (4779254) 4779254..4780195 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QDW67_RS23300 (4780240) 4780240..4780677 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T277692 WP_000897305.1 NZ_CP122681:c4775718-4775407 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT277692 WP_000356395.1 NZ_CP122681:c4775406-4775116 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References