Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1175659..1175884 Replicon chromosome
Accession NC_017906
Organism Escherichia coli Xuzhou21

Toxin (Protein)


Gene name hokW Uniprot ID -
Locus tag CDCO157_RS05635 Protein ID WP_000813263.1
Coordinates 1175729..1175884 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 1175659..1175717 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDCO157_RS05610 1170934..1172025 + 1092 WP_001205823.1 hypothetical protein -
CDCO157_RS05615 1172032..1172778 + 747 WP_000788751.1 ATP-binding protein -
CDCO157_RS05620 1172800..1173570 + 771 WP_000450992.1 DUF1627 domain-containing protein -
CDCO157_RS05625 1173586..1173999 + 414 WP_001151233.1 DUF977 family protein -
CDCO157_RS05630 1174351..1175124 - 774 WP_000160654.1 alpha/beta hydrolase -
- 1175659..1175717 - 59 - - Antitoxin
CDCO157_RS05635 1175729..1175884 + 156 WP_000813263.1 type I toxin-antitoxin system toxin HokD Toxin
CDCO157_RS30925 1176052..1176330 + 279 WP_001341388.1 hypothetical protein -
CDCO157_RS05645 1176332..1177381 + 1050 WP_001265172.1 DUF968 domain-containing protein -
CDCO157_RS05650 1177394..1177765 + 372 WP_001217436.1 RusA family crossover junction endodeoxyribonuclease -
CDCO157_RS05655 1177755..1178126 + 372 WP_000090264.1 antitermination protein -
CDCO157_RS05660 1178278..1179096 + 819 WP_000265265.1 CPBP family intramembrane metalloprotease -
CDCO157_RS05665 1179383..1179579 + 197 Protein_1067 TrmB family transcriptional regulator -
CDCO157_RS05670 1179717..1180430 + 714 WP_000261909.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5722.86 Da        Isoelectric Point: 6.1531

>T27768 WP_000813263.1 NC_017906:1175729-1175884 [Escherichia coli Xuzhou21]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T27768 NC_017906:1175729-1175884 [Escherichia coli Xuzhou21]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT27768 NC_017906:c1175717-1175659 [Escherichia coli Xuzhou21]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References