Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1184925..1185652 Replicon chromosome
Accession NZ_CP122681
Organism Escherichia coli strain ETEC4068

Toxin (Protein)


Gene name higB Uniprot ID V0YLE2
Locus tag QDW67_RS05680 Protein ID WP_000547555.1
Coordinates 1184925..1185236 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW67_RS05685 Protein ID WP_000126294.1
Coordinates 1185233..1185652 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW67_RS05655 (1180860) 1180860..1182569 + 1710 WP_063086195.1 formate hydrogenlyase subunit HycE -
QDW67_RS05660 (1182579) 1182579..1183121 + 543 WP_000493785.1 formate hydrogenlyase subunit HycF -
QDW67_RS05665 (1183121) 1183121..1183888 + 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
QDW67_RS05670 (1183885) 1183885..1184295 + 411 WP_001291921.1 formate hydrogenlyase assembly protein HycH -
QDW67_RS05675 (1184288) 1184288..1184758 + 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
QDW67_RS05680 (1184925) 1184925..1185236 + 312 WP_000547555.1 type II toxin-antitoxin system HigB family toxin Toxin
QDW67_RS05685 (1185233) 1185233..1185652 + 420 WP_000126294.1 helix-turn-helix domain-containing protein Antitoxin
QDW67_RS05690 (1185731) 1185731..1187155 - 1425 WP_063086210.1 6-phospho-beta-glucosidase AscB -
QDW67_RS05695 (1187164) 1187164..1188621 - 1458 WP_001107888.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
QDW67_RS05700 (1188881) 1188881..1189891 + 1011 WP_029130985.1 DNA-binding transcriptional regulator AscG -
QDW67_RS05705 (1190040) 1190040..1190567 + 528 WP_001078777.1 electron transport protein HydN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12439.18 Da        Isoelectric Point: 9.5146

>T277677 WP_000547555.1 NZ_CP122681:1184925-1185236 [Escherichia coli]
MHIISKAPFEECARKYPNDALALHSLYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT277677 WP_000126294.1 NZ_CP122681:1185233-1185652 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0YLE2

Antitoxin

Source ID Structure

References