Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 620924..621723 Replicon chromosome
Accession NZ_CP122681
Organism Escherichia coli strain ETEC4068

Toxin (Protein)


Gene name yhaV Uniprot ID A0A3A6SBL4
Locus tag QDW67_RS02995 Protein ID WP_062875446.1
Coordinates 620924..621388 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDW67_RS03000 Protein ID WP_001307405.1
Coordinates 621388..621723 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW67_RS02965 (615925) 615925..616359 - 435 WP_063086247.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDW67_RS02970 (616377) 616377..617255 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QDW67_RS02975 (617245) 617245..618024 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDW67_RS02980 (618035) 618035..618508 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDW67_RS02985 (618531) 618531..619811 - 1281 WP_063086249.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDW67_RS02990 (620060) 620060..620869 + 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
QDW67_RS02995 (620924) 620924..621388 - 465 WP_062875446.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDW67_RS03000 (621388) 621388..621723 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDW67_RS03005 (621872) 621872..623443 - 1572 WP_001273756.1 galactarate dehydratase -
QDW67_RS03010 (623818) 623818..625152 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QDW67_RS03015 (625168) 625168..625943 + 776 Protein_589 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 620924..632217 11293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17844.22 Da        Isoelectric Point: 9.4942

>T277674 WP_062875446.1 NZ_CP122681:c621388-620924 [Escherichia coli]
MDFPQRVNSWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETD

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277674 WP_001307405.1 NZ_CP122681:c621723-621388 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6SBL4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References