Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4889970..4890572 Replicon chromosome
Accession NZ_CP122679
Organism Escherichia coli strain ETEC4069

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QDW53_RS24205 Protein ID WP_000897305.1
Coordinates 4890261..4890572 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW53_RS24200 Protein ID WP_000356395.1
Coordinates 4889970..4890260 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW53_RS24165 (4885594) 4885594..4886496 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QDW53_RS24170 (4886493) 4886493..4887128 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QDW53_RS24175 (4887125) 4887125..4888054 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QDW53_RS24180 (4888236) 4888236..4888478 - 243 WP_001306649.1 protein YiiF -
QDW53_RS24185 (4888697) 4888697..4888915 - 219 WP_001295676.1 CopG family transcriptional regulator -
QDW53_RS24190 (4889334) 4889334..4889612 - 279 WP_001306650.1 hypothetical protein -
QDW53_RS24195 (4889664) 4889664..4889885 - 222 WP_001550354.1 hypothetical protein -
QDW53_RS24200 (4889970) 4889970..4890260 - 291 WP_000356395.1 NadS family protein Antitoxin
QDW53_RS24205 (4890261) 4890261..4890572 - 312 WP_000897305.1 hypothetical protein Toxin
QDW53_RS24210 (4890801) 4890801..4891709 + 909 WP_001306651.1 alpha/beta hydrolase -
QDW53_RS24215 (4891878) 4891878..4892792 - 915 WP_225102955.1 transposase -
QDW53_RS24220 (4892805) 4892805..4893692 - 888 Protein_4736 hypothetical protein -
QDW53_RS24225 (4894108) 4894108..4895049 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QDW53_RS24230 (4895094) 4895094..4895531 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T277672 WP_000897305.1 NZ_CP122679:c4890572-4890261 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT277672 WP_000356395.1 NZ_CP122679:c4890260-4889970 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References