Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1134877..1135604 Replicon chromosome
Accession NZ_CP122679
Organism Escherichia coli strain ETEC4069

Toxin (Protein)


Gene name higB Uniprot ID V0YLE2
Locus tag QDW53_RS05445 Protein ID WP_000547555.1
Coordinates 1134877..1135188 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW53_RS05450 Protein ID WP_000126294.1
Coordinates 1135185..1135604 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW53_RS05420 (1130812) 1130812..1132521 + 1710 WP_063086195.1 formate hydrogenlyase subunit HycE -
QDW53_RS05425 (1132531) 1132531..1133073 + 543 WP_000493785.1 formate hydrogenlyase subunit HycF -
QDW53_RS05430 (1133073) 1133073..1133840 + 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
QDW53_RS05435 (1133837) 1133837..1134247 + 411 WP_001291921.1 formate hydrogenlyase assembly protein HycH -
QDW53_RS05440 (1134240) 1134240..1134710 + 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
QDW53_RS05445 (1134877) 1134877..1135188 + 312 WP_000547555.1 type II toxin-antitoxin system HigB family toxin Toxin
QDW53_RS05450 (1135185) 1135185..1135604 + 420 WP_000126294.1 helix-turn-helix domain-containing protein Antitoxin
QDW53_RS05455 (1135683) 1135683..1137107 - 1425 WP_063086210.1 6-phospho-beta-glucosidase AscB -
QDW53_RS05460 (1137116) 1137116..1138573 - 1458 WP_001107888.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
QDW53_RS05465 (1138833) 1138833..1139843 + 1011 WP_029130985.1 DNA-binding transcriptional regulator AscG -
QDW53_RS05470 (1139992) 1139992..1140519 + 528 WP_001078777.1 electron transport protein HydN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12439.18 Da        Isoelectric Point: 9.5146

>T277655 WP_000547555.1 NZ_CP122679:1134877-1135188 [Escherichia coli]
MHIISKAPFEECARKYPNDALALHSLYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT277655 WP_000126294.1 NZ_CP122679:1135185-1135604 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0YLE2

Antitoxin

Source ID Structure

References