Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 616341..617140 Replicon chromosome
Accession NZ_CP122679
Organism Escherichia coli strain ETEC4069

Toxin (Protein)


Gene name yhaV Uniprot ID A0A3A6SBL4
Locus tag QDW53_RS02970 Protein ID WP_062875446.1
Coordinates 616341..616805 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDW53_RS02975 Protein ID WP_001307405.1
Coordinates 616805..617140 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW53_RS02940 (611342) 611342..611776 - 435 WP_063086247.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDW53_RS02945 (611794) 611794..612672 - 879 WP_192297513.1 PTS N-acetylgalactosamine transporter subunit IID -
QDW53_RS02950 (612662) 612662..613441 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDW53_RS02955 (613452) 613452..613925 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDW53_RS02960 (613948) 613948..615228 - 1281 WP_063086249.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDW53_RS02965 (615477) 615477..616286 + 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
QDW53_RS02970 (616341) 616341..616805 - 465 WP_062875446.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDW53_RS02975 (616805) 616805..617140 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDW53_RS02980 (617289) 617289..618860 - 1572 WP_001273756.1 galactarate dehydratase -
QDW53_RS02985 (619235) 619235..620569 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QDW53_RS02990 (620585) 620585..621360 + 776 Protein_584 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 616341..627633 11292


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17844.22 Da        Isoelectric Point: 9.4942

>T277652 WP_062875446.1 NZ_CP122679:c616805-616341 [Escherichia coli]
MDFPQRVNSWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETD

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277652 WP_001307405.1 NZ_CP122679:c617140-616805 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6SBL4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References