Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 94658..94922 Replicon plasmid unnamed2
Accession NZ_CP122678
Organism Escherichia coli strain ETEC4070

Toxin (Protein)


Gene name pndA Uniprot ID U9Y6M3
Locus tag QDW57_RS25670 Protein ID WP_001331364.1
Coordinates 94658..94810 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 94865..94922 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW57_RS25640 (89935) 89935..92103 + 2169 WP_001774191.1 DotA/TraY family protein -
QDW57_RS25645 (92177) 92177..92827 + 651 WP_001178506.1 plasmid IncI1-type surface exclusion protein ExcA -
QDW57_RS25650 (92899) 92899..93108 - 210 WP_000062603.1 HEAT repeat domain-containing protein -
QDW57_RS25655 (93500) 93500..93676 + 177 WP_001054897.1 hypothetical protein -
QDW57_RS25660 (93741) 93741..93836 - 96 WP_001303310.1 DinQ-like type I toxin DqlB -
QDW57_RS25665 (94335) 94335..94586 + 252 WP_001291964.1 hypothetical protein -
QDW57_RS25670 (94658) 94658..94810 - 153 WP_001331364.1 Hok/Gef family protein Toxin
- (94865) 94865..94922 + 58 NuclAT_0 - Antitoxin
- (94865) 94865..94922 + 58 NuclAT_0 - Antitoxin
- (94865) 94865..94922 + 58 NuclAT_0 - Antitoxin
- (94865) 94865..94922 + 58 NuclAT_0 - Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B - 1..95101 95101


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5775.13 Da        Isoelectric Point: 8.7948

>T277648 WP_001331364.1 NZ_CP122678:c94810-94658 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT277648 NZ_CP122678:94865-94922 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5W9M382

Antitoxin

Download structure file

References