Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4860782..4861384 Replicon chromosome
Accession NZ_CP122676
Organism Escherichia coli strain ETEC4070

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QDW57_RS23870 Protein ID WP_000897305.1
Coordinates 4861073..4861384 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW57_RS23865 Protein ID WP_000356395.1
Coordinates 4860782..4861072 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW57_RS23830 (4856406) 4856406..4857308 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QDW57_RS23835 (4857305) 4857305..4857940 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QDW57_RS23840 (4857937) 4857937..4858866 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QDW57_RS23845 (4859048) 4859048..4859290 - 243 WP_001306649.1 protein YiiF -
QDW57_RS23850 (4859509) 4859509..4859727 - 219 WP_001295676.1 CopG family transcriptional regulator -
QDW57_RS23855 (4860146) 4860146..4860424 - 279 WP_001306650.1 hypothetical protein -
QDW57_RS23860 (4860476) 4860476..4860697 - 222 WP_001550354.1 hypothetical protein -
QDW57_RS23865 (4860782) 4860782..4861072 - 291 WP_000356395.1 NadS family protein Antitoxin
QDW57_RS23870 (4861073) 4861073..4861384 - 312 WP_000897305.1 hypothetical protein Toxin
QDW57_RS23875 (4861613) 4861613..4862521 + 909 WP_001306651.1 alpha/beta hydrolase -
QDW57_RS23880 (4862690) 4862690..4863604 - 915 WP_225102955.1 transposase -
QDW57_RS23885 (4863617) 4863617..4864504 - 888 Protein_4668 hypothetical protein -
QDW57_RS23890 (4864920) 4864920..4865861 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QDW57_RS23895 (4865906) 4865906..4866343 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T277647 WP_000897305.1 NZ_CP122676:c4861384-4861073 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT277647 WP_000356395.1 NZ_CP122676:c4861072-4860782 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References