Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1138410..1139137 Replicon chromosome
Accession NZ_CP122676
Organism Escherichia coli strain ETEC4070

Toxin (Protein)


Gene name higB Uniprot ID V0YLE2
Locus tag QDW57_RS05485 Protein ID WP_000547555.1
Coordinates 1138410..1138721 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW57_RS05490 Protein ID WP_000126294.1
Coordinates 1138718..1139137 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW57_RS05460 (1134345) 1134345..1136054 + 1710 WP_063086195.1 formate hydrogenlyase subunit HycE -
QDW57_RS05465 (1136064) 1136064..1136606 + 543 WP_000493785.1 formate hydrogenlyase subunit HycF -
QDW57_RS05470 (1136606) 1136606..1137373 + 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
QDW57_RS05475 (1137370) 1137370..1137780 + 411 WP_001291921.1 formate hydrogenlyase assembly protein HycH -
QDW57_RS05480 (1137773) 1137773..1138243 + 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
QDW57_RS05485 (1138410) 1138410..1138721 + 312 WP_000547555.1 type II toxin-antitoxin system HigB family toxin Toxin
QDW57_RS05490 (1138718) 1138718..1139137 + 420 WP_000126294.1 helix-turn-helix domain-containing protein Antitoxin
QDW57_RS05495 (1139216) 1139216..1140640 - 1425 WP_063086210.1 6-phospho-beta-glucosidase AscB -
QDW57_RS05500 (1140649) 1140649..1142106 - 1458 WP_001107888.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
QDW57_RS05505 (1142366) 1142366..1143376 + 1011 WP_029130985.1 DNA-binding transcriptional regulator AscG -
QDW57_RS05510 (1143525) 1143525..1144052 + 528 WP_001078777.1 electron transport protein HydN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12439.18 Da        Isoelectric Point: 9.5146

>T277630 WP_000547555.1 NZ_CP122676:1138410-1138721 [Escherichia coli]
MHIISKAPFEECARKYPNDALALHSLYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT277630 WP_000126294.1 NZ_CP122676:1138718-1139137 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0YLE2

Antitoxin

Source ID Structure

References