Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 94661..94925 Replicon plasmid unnamed1
Accession NZ_CP122674
Organism Escherichia coli strain ETEC4071

Toxin (Protein)


Gene name pndA Uniprot ID U9Y6M3
Locus tag QDW56_RS25365 Protein ID WP_001331364.1
Coordinates 94661..94813 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 94868..94925 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW56_RS25335 (89938) 89938..92106 + 2169 WP_001774191.1 DotA/TraY family protein -
QDW56_RS25340 (92180) 92180..92830 + 651 WP_001178506.1 plasmid IncI1-type surface exclusion protein ExcA -
QDW56_RS25345 (92902) 92902..93111 - 210 WP_000062603.1 HEAT repeat domain-containing protein -
QDW56_RS25350 (93503) 93503..93679 + 177 WP_001054897.1 hypothetical protein -
QDW56_RS25355 (93744) 93744..93839 - 96 WP_001303310.1 DinQ-like type I toxin DqlB -
QDW56_RS25360 (94338) 94338..94589 + 252 WP_001291964.1 hypothetical protein -
QDW56_RS25365 (94661) 94661..94813 - 153 WP_001331364.1 Hok/Gef family protein Toxin
- (94868) 94868..94925 + 58 NuclAT_0 - Antitoxin
- (94868) 94868..94925 + 58 NuclAT_0 - Antitoxin
- (94868) 94868..94925 + 58 NuclAT_0 - Antitoxin
- (94868) 94868..94925 + 58 NuclAT_0 - Antitoxin

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B - 1..95104 95104


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-46)


Sequences


Toxin        


Download         Length: 51 a.a.        Molecular weight: 5775.13 Da        Isoelectric Point: 8.7948

>T277624 WP_001331364.1 NZ_CP122674:c94813-94661 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp


Antitoxin


Download         Length: 58 bp

>AT277624 NZ_CP122674:94868-94925 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A5W9M382


Antitoxin

Download structure file

References