Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4860786..4861388 Replicon chromosome
Accession NZ_CP122673
Organism Escherichia coli strain ETEC4071

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QDW56_RS23875 Protein ID WP_000897305.1
Coordinates 4861077..4861388 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW56_RS23870 Protein ID WP_000356395.1
Coordinates 4860786..4861076 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW56_RS23835 (4856409) 4856409..4857311 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QDW56_RS23840 (4857308) 4857308..4857943 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QDW56_RS23845 (4857940) 4857940..4858869 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QDW56_RS23850 (4859051) 4859051..4859293 - 243 WP_001306649.1 protein YiiF -
QDW56_RS23855 (4859512) 4859512..4859730 - 219 WP_001295676.1 CopG family transcriptional regulator -
QDW56_RS23860 (4860149) 4860149..4860427 - 279 WP_001306650.1 hypothetical protein -
QDW56_RS23865 (4860489) 4860489..4860701 - 213 WP_000197769.1 hypothetical protein -
QDW56_RS23870 (4860786) 4860786..4861076 - 291 WP_000356395.1 NadS family protein Antitoxin
QDW56_RS23875 (4861077) 4861077..4861388 - 312 WP_000897305.1 hypothetical protein Toxin
QDW56_RS23880 (4861617) 4861617..4862525 + 909 WP_001306651.1 alpha/beta hydrolase -
QDW56_RS23885 (4862694) 4862694..4863608 - 915 WP_225102955.1 transposase -
QDW56_RS23890 (4863621) 4863621..4864508 - 888 Protein_4669 hypothetical protein -
QDW56_RS23895 (4864924) 4864924..4865865 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QDW56_RS23900 (4865910) 4865910..4866347 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T277623 WP_000897305.1 NZ_CP122673:c4861388-4861077 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT277623 WP_000356395.1 NZ_CP122673:c4861076-4860786 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References