Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1138412..1139139 Replicon chromosome
Accession NZ_CP122673
Organism Escherichia coli strain ETEC4071

Toxin (Protein)


Gene name higB Uniprot ID V0YLE2
Locus tag QDW56_RS05485 Protein ID WP_000547555.1
Coordinates 1138412..1138723 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW56_RS05490 Protein ID WP_000126294.1
Coordinates 1138720..1139139 (+) Length 140 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW56_RS05460 (1134347) 1134347..1136056 + 1710 WP_063086195.1 formate hydrogenlyase subunit HycE -
QDW56_RS05465 (1136066) 1136066..1136608 + 543 WP_000493785.1 formate hydrogenlyase subunit HycF -
QDW56_RS05470 (1136608) 1136608..1137375 + 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
QDW56_RS05475 (1137372) 1137372..1137782 + 411 WP_001291921.1 formate hydrogenlyase assembly protein HycH -
QDW56_RS05480 (1137775) 1137775..1138245 + 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
QDW56_RS05485 (1138412) 1138412..1138723 + 312 WP_000547555.1 type II toxin-antitoxin system HigB family toxin Toxin
QDW56_RS05490 (1138720) 1138720..1139139 + 420 WP_000126294.1 helix-turn-helix domain-containing protein Antitoxin
QDW56_RS05495 (1139218) 1139218..1140642 - 1425 WP_063086210.1 6-phospho-beta-glucosidase AscB -
QDW56_RS05500 (1140651) 1140651..1142108 - 1458 WP_001107888.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
QDW56_RS05505 (1142368) 1142368..1143378 + 1011 WP_029130985.1 DNA-binding transcriptional regulator AscG -
QDW56_RS05510 (1143527) 1143527..1144054 + 528 WP_001078777.1 electron transport protein HydN -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12439.18 Da        Isoelectric Point: 9.5146

>T277606 WP_000547555.1 NZ_CP122673:1138412-1138723 [Escherichia coli]
MHIISKAPFEECARKYPNDALALHSLYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp


Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT277606 WP_000126294.1 NZ_CP122673:1138720-1139139 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V0YLE2


Antitoxin

Source ID Structure

References