Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 617893..618692 Replicon chromosome
Accession NZ_CP122673
Organism Escherichia coli strain ETEC4071

Toxin (Protein)


Gene name yhaV Uniprot ID A0A3A6SBL4
Locus tag QDW56_RS02985 Protein ID WP_062875446.1
Coordinates 617893..618357 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDW56_RS02990 Protein ID WP_001307405.1
Coordinates 618357..618692 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW56_RS02955 (612894) 612894..613328 - 435 WP_063086247.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDW56_RS02960 (613346) 613346..614224 - 879 WP_192297513.1 PTS N-acetylgalactosamine transporter subunit IID -
QDW56_RS02965 (614214) 614214..614993 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDW56_RS02970 (615004) 615004..615477 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDW56_RS02975 (615500) 615500..616780 - 1281 WP_063086249.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDW56_RS02980 (617029) 617029..617838 + 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
QDW56_RS02985 (617893) 617893..618357 - 465 WP_062875446.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDW56_RS02990 (618357) 618357..618692 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDW56_RS02995 (618841) 618841..620412 - 1572 WP_001273756.1 galactarate dehydratase -
QDW56_RS03000 (620787) 620787..622121 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QDW56_RS03005 (622137) 622137..622912 + 776 Protein_587 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 617893..629184 11291


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17844.22 Da        Isoelectric Point: 9.4942

>T277603 WP_062875446.1 NZ_CP122673:c618357-617893 [Escherichia coli]
MDFPQRVNSWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETD

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277603 WP_001307405.1 NZ_CP122673:c618692-618357 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6SBL4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References