Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3751483..3752024 Replicon chromosome
Accession NZ_CP122660
Organism Escherichia coli strain ETEC4073

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag QDY26_RS18555 Protein ID WP_000615983.1
Coordinates 3751746..3752024 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag QDY26_RS18550 Protein ID WP_000729703.1
Coordinates 3751483..3751743 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY26_RS18530 (3747158) 3747158..3747943 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
QDY26_RS18535 (3747915) 3747915..3749627 + 1713 Protein_3625 flagellar biosynthesis protein FlhA -
QDY26_RS18540 (3749851) 3749851..3750348 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
QDY26_RS18545 (3750524) 3750524..3751273 - 750 WP_000056849.1 C40 family peptidase -
QDY26_RS18550 (3751483) 3751483..3751743 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QDY26_RS18555 (3751746) 3751746..3752024 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QDY26_RS18560 (3752180) 3752180..3752920 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QDY26_RS18565 (3752891) 3752891..3753658 - 768 WP_000333380.1 class II glutamine amidotransferase -
QDY26_RS18570 (3753864) 3753864..3754442 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T277591 WP_000615983.1 NZ_CP122660:3751746-3752024 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT277591 WP_000729703.1 NZ_CP122660:3751483-3751743 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References