Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3745286..3745980 Replicon chromosome
Accession NZ_CP122660
Organism Escherichia coli strain ETEC4073

Toxin (Protein)


Gene name yafO Uniprot ID Q47157
Locus tag QDY26_RS18515 Protein ID WP_001263489.1
Coordinates 3745286..3745684 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1QAE3
Locus tag QDY26_RS18520 Protein ID WP_000554758.1
Coordinates 3745687..3745980 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
- (3740874) 3740874..3740954 - 81 NuclAT_11 - -
- (3740874) 3740874..3740954 - 81 NuclAT_11 - -
- (3740874) 3740874..3740954 - 81 NuclAT_11 - -
- (3740874) 3740874..3740954 - 81 NuclAT_11 - -
QDY26_RS18490 (3741550) 3741550..3742008 - 459 WP_001291990.1 xanthine phosphoribosyltransferase -
QDY26_RS18495 (3742269) 3742269..3743726 + 1458 WP_001292994.1 cytosol nonspecific dipeptidase -
QDY26_RS18500 (3743783) 3743783..3744304 - 522 Protein_3618 peptide chain release factor H -
QDY26_RS18505 (3744300) 3744300..3744506 - 207 Protein_3619 RtcB family protein -
QDY26_RS18510 (3744824) 3744824..3745276 - 453 WP_001059892.1 GNAT family N-acetyltransferase -
QDY26_RS18515 (3745286) 3745286..3745684 - 399 WP_001263489.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
QDY26_RS18520 (3745687) 3745687..3745980 - 294 WP_000554758.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
QDY26_RS18525 (3746032) 3746032..3747087 - 1056 WP_001226164.1 DNA polymerase IV -
QDY26_RS18530 (3747158) 3747158..3747943 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
QDY26_RS18535 (3747915) 3747915..3749627 + 1713 Protein_3625 flagellar biosynthesis protein FlhA -
QDY26_RS18540 (3749851) 3749851..3750348 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15487.84 Da        Isoelectric Point: 7.4215

>T277590 WP_001263489.1 NZ_CP122660:c3745684-3745286 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.76 Da        Isoelectric Point: 5.2170

>AT277590 WP_000554758.1 NZ_CP122660:c3745980-3745687 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090J8B1

Antitoxin

Source ID Structure
AlphaFold DB S1QAE3

References