Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1835752..1836254 Replicon chromosome
Accession NZ_CP122660
Organism Escherichia coli strain ETEC4073

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag QDY26_RS08790 Protein ID WP_000767829.1
Coordinates 1836000..1836254 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S1Y4D6
Locus tag QDY26_RS08785 Protein ID WP_001259254.1
Coordinates 1835752..1836003 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY26_RS08760 (1830930) 1830930..1831997 - 1068 WP_016232166.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QDY26_RS08765 (1831997) 1831997..1833067 - 1071 WP_000108986.1 histidinol-phosphate transaminase -
QDY26_RS08770 (1833064) 1833064..1834368 - 1305 WP_046788605.1 histidinol dehydrogenase -
QDY26_RS08775 (1834374) 1834374..1835273 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QDY26_RS08780 (1835419) 1835419..1835469 - 51 WP_001364200.1 his operon leader peptide -
QDY26_RS08785 (1835752) 1835752..1836003 + 252 WP_001259254.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QDY26_RS08790 (1836000) 1836000..1836254 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QDY26_RS08795 (1836337) 1836337..1837161 + 825 WP_000754737.1 SDR family oxidoreductase -
QDY26_RS08800 (1837207) 1837207..1838136 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
QDY26_RS08805 (1838351) 1838351..1838413 + 63 WP_010723108.1 membrane protein YoeI -
QDY26_RS08810 (1838403) 1838403..1839761 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QDY26_RS08815 (1839939) 1839939..1840997 + 1059 WP_000492313.1 thiosulfate utilization transporter TsuA/YeeE -
QDY26_RS08820 (1841011) 1841011..1841238 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T277579 WP_000767829.1 NZ_CP122660:1836000-1836254 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9292.57 Da        Isoelectric Point: 4.5822

>AT277579 WP_001259254.1 NZ_CP122660:1835752-1836003 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGIGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A2S1Y4D6

References