Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1854991..1855493 Replicon chromosome
Accession NZ_CP122655
Organism Escherichia coli strain ETEC4074

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag QDW60_RS08970 Protein ID WP_001471733.1
Coordinates 1855239..1855493 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QDW60_RS08965 Protein ID WP_001259255.1
Coordinates 1854991..1855242 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW60_RS08940 (1850169) 1850169..1851236 - 1068 WP_001374028.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QDW60_RS08945 (1851236) 1851236..1852306 - 1071 WP_001374029.1 histidinol-phosphate transaminase -
QDW60_RS08950 (1852303) 1852303..1853607 - 1305 WP_001748534.1 histidinol dehydrogenase -
QDW60_RS08955 (1853613) 1853613..1854512 - 900 WP_001374031.1 ATP phosphoribosyltransferase -
QDW60_RS08960 (1854658) 1854658..1854708 - 51 WP_001364200.1 his operon leader peptide -
QDW60_RS08965 (1854991) 1854991..1855242 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QDW60_RS08970 (1855239) 1855239..1855493 + 255 WP_001471733.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QDW60_RS08975 (1855576) 1855576..1856400 + 825 WP_000754737.1 SDR family oxidoreductase -
QDW60_RS08980 (1856446) 1856446..1857375 + 930 WP_001374016.1 LysR substrate-binding domain-containing protein -
QDW60_RS08985 (1857590) 1857590..1857652 + 63 WP_010723108.1 membrane protein YoeI -
QDW60_RS08990 (1857642) 1857642..1859000 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10195.64 Da        Isoelectric Point: 8.0353

>T277556 WP_001471733.1 NZ_CP122655:1855239-1855493 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDIRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT277556 WP_001259255.1 NZ_CP122655:1854991-1855242 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References