Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 755562..756255 Replicon chromosome
Accession NZ_CP122655
Organism Escherichia coli strain ETEC4074

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QDW60_RS03695 Protein ID WP_000415584.1
Coordinates 755562..755858 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QDW60_RS03700 Protein ID WP_000650107.1
Coordinates 755860..756255 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW60_RS03660 (751118) 751118..751282 + 165 Protein_718 DUF2645 domain-containing protein -
QDW60_RS03670 (752051) 752051..752227 + 177 Protein_720 DUF2645 domain-containing protein -
QDW60_RS03675 (752273) 752273..753622 - 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
QDW60_RS03680 (753619) 753619..754278 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
QDW60_RS03685 (754430) 754430..754822 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QDW60_RS03690 (754875) 754875..755357 + 483 WP_000183505.1 GyrI-like domain-containing protein -
QDW60_RS03695 (755562) 755562..755858 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QDW60_RS03700 (755860) 755860..756255 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QDW60_RS03705 (756388) 756388..757995 + 1608 WP_032083699.1 ABC transporter substrate-binding protein -
QDW60_RS03710 (758133) 758133..760391 + 2259 WP_001618856.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 734339..760391 26052
- inside Prophage - - 737076..760391 23315


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T277553 WP_000415584.1 NZ_CP122655:755562-755858 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT277553 WP_000650107.1 NZ_CP122655:755860-756255 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References