Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4818992..4819594 Replicon chromosome
Accession NZ_CP122652
Organism Escherichia coli strain ETEC4075

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QDW61_RS23620 Protein ID WP_000897305.1
Coordinates 4819283..4819594 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW61_RS23615 Protein ID WP_000356395.1
Coordinates 4818992..4819282 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW61_RS23580 (4814615) 4814615..4815517 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QDW61_RS23585 (4815514) 4815514..4816149 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QDW61_RS23590 (4816146) 4816146..4817075 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QDW61_RS23595 (4817257) 4817257..4817499 - 243 WP_001306649.1 protein YiiF -
QDW61_RS23600 (4817718) 4817718..4817936 - 219 WP_001295676.1 CopG family transcriptional regulator -
QDW61_RS23605 (4818355) 4818355..4818633 - 279 WP_001306650.1 hypothetical protein -
QDW61_RS23610 (4818695) 4818695..4818907 - 213 WP_000197769.1 hypothetical protein -
QDW61_RS23615 (4818992) 4818992..4819282 - 291 WP_000356395.1 NadS family protein Antitoxin
QDW61_RS23620 (4819283) 4819283..4819594 - 312 WP_000897305.1 hypothetical protein Toxin
QDW61_RS23625 (4819823) 4819823..4820731 + 909 WP_001306651.1 alpha/beta hydrolase -
QDW61_RS23630 (4820900) 4820900..4821814 - 915 WP_225102955.1 transposase -
QDW61_RS23635 (4821827) 4821827..4822714 - 888 Protein_4618 hypothetical protein -
QDW61_RS23640 (4823130) 4823130..4824071 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QDW61_RS23645 (4824116) 4824116..4824553 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T277544 WP_000897305.1 NZ_CP122652:c4819594-4819283 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT277544 WP_000356395.1 NZ_CP122652:c4819282-4818992 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References