Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1184820..1185547 Replicon chromosome
Accession NZ_CP122652
Organism Escherichia coli strain ETEC4075

Toxin (Protein)


Gene name higB Uniprot ID V0YLE2
Locus tag QDW61_RS05675 Protein ID WP_000547555.1
Coordinates 1184820..1185131 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW61_RS05680 Protein ID WP_000126294.1
Coordinates 1185128..1185547 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW61_RS05650 (1180755) 1180755..1182464 + 1710 WP_063086195.1 formate hydrogenlyase subunit HycE -
QDW61_RS05655 (1182474) 1182474..1183016 + 543 WP_000493785.1 formate hydrogenlyase subunit HycF -
QDW61_RS05660 (1183016) 1183016..1183783 + 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
QDW61_RS05665 (1183780) 1183780..1184190 + 411 WP_001291921.1 formate hydrogenlyase assembly protein HycH -
QDW61_RS05670 (1184183) 1184183..1184653 + 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
QDW61_RS05675 (1184820) 1184820..1185131 + 312 WP_000547555.1 type II toxin-antitoxin system HigB family toxin Toxin
QDW61_RS05680 (1185128) 1185128..1185547 + 420 WP_000126294.1 helix-turn-helix domain-containing protein Antitoxin
QDW61_RS05685 (1185626) 1185626..1187050 - 1425 WP_063086210.1 6-phospho-beta-glucosidase AscB -
QDW61_RS05690 (1187059) 1187059..1188516 - 1458 WP_001107888.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
QDW61_RS05695 (1188776) 1188776..1189786 + 1011 WP_029130985.1 DNA-binding transcriptional regulator AscG -
QDW61_RS05700 (1189935) 1189935..1190462 + 528 WP_001078777.1 electron transport protein HydN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12439.18 Da        Isoelectric Point: 9.5146

>T277526 WP_000547555.1 NZ_CP122652:1184820-1185131 [Escherichia coli]
MHIISKAPFEECARKYPNDALALHSLYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT277526 WP_000126294.1 NZ_CP122652:1185128-1185547 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0YLE2

Antitoxin

Source ID Structure

References