Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4955624..4956226 Replicon chromosome
Accession NZ_CP122648
Organism Escherichia coli strain ETEC4077

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QDY56_RS24545 Protein ID WP_000897305.1
Coordinates 4955915..4956226 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDY56_RS24540 Protein ID WP_000356395.1
Coordinates 4955624..4955914 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY56_RS24505 (4951248) 4951248..4952150 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QDY56_RS24510 (4952147) 4952147..4952782 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QDY56_RS24515 (4952779) 4952779..4953708 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QDY56_RS24520 (4953890) 4953890..4954132 - 243 WP_001306649.1 protein YiiF -
QDY56_RS24525 (4954351) 4954351..4954569 - 219 WP_001295676.1 CopG family transcriptional regulator -
QDY56_RS24530 (4954988) 4954988..4955266 - 279 WP_001306650.1 hypothetical protein -
QDY56_RS24535 (4955318) 4955318..4955539 - 222 WP_001550354.1 hypothetical protein -
QDY56_RS24540 (4955624) 4955624..4955914 - 291 WP_000356395.1 NadS family protein Antitoxin
QDY56_RS24545 (4955915) 4955915..4956226 - 312 WP_000897305.1 hypothetical protein Toxin
QDY56_RS24550 (4956455) 4956455..4957363 + 909 WP_001306651.1 alpha/beta hydrolase -
QDY56_RS24555 (4957532) 4957532..4958446 - 915 WP_225102955.1 transposase -
QDY56_RS24560 (4958459) 4958459..4959346 - 888 Protein_4807 hypothetical protein -
QDY56_RS24565 (4959762) 4959762..4960703 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QDY56_RS24570 (4960748) 4960748..4961185 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T277520 WP_000897305.1 NZ_CP122648:c4956226-4955915 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT277520 WP_000356395.1 NZ_CP122648:c4955914-4955624 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References