Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 936006..936510 Replicon chromosome
Accession NC_017857
Organism Methylophaga nitratireducenticrescens

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag Q7A_RS04470 Protein ID WP_202971552.1
Coordinates 936006..936230 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Q7A_RS04475 Protein ID WP_202971553.1
Coordinates 936220..936510 (+) Length 97 a.a.

Genomic Context

Q7A_RS04435Q7A_RS04440Q7A_RS15165Q7A_RS04445Q7A_RS04450Q7A_RS04455Q7A_RS04460Q7A_RS04465Q7A_RS04470Q7A_RS04475Q7A_RS04485Q7A_RS04500Q7A_RS04480Q7A_RS04490Q7A_RS04495
Location: 931835..932140 (306 bp)
Type: Others
Protein ID: WP_041354369.1
Location: 932330..933082 (753 bp)
Type: Others
Protein ID: WP_014706132.1
Location: 933315..933467 (153 bp)
Type: Others
Protein ID: WP_014706133.1
Location: 933590..934501 (912 bp)
Type: Others
Protein ID: WP_014706134.1
Location: 934642..934875 (234 bp)
Type: Others
Protein ID: WP_014706135.1
Location: 934862..935128 (267 bp)
Type: Others
Protein ID: WP_041354373.1
Location: 935165..935380 (216 bp)
Type: Others
Protein ID: WP_041354375.1
Location: 935445..935783 (339 bp)
Type: Others
Protein ID: WP_014706136.1
Location: 936006..936230 (225 bp)
Type: Toxin
Protein ID: WP_202971552.1
Location: 936220..936510 (291 bp)
Type: Antitoxin
Protein ID: WP_202971553.1
Location: 937800..938138 (339 bp)
Type: Others
Protein ID: WP_014706140.1
Location: 939110..940957 (1848 bp)
Type: Others
Protein ID: WP_014706143.1
Location: 936552..937397 (846 bp)
Type: Others
Protein ID: WP_014706139.1
Location: 938200..938454 (255 bp)
Type: Others
Protein ID: WP_014706141.1
Location: 938451..938702 (252 bp)
Type: Others
Protein ID: WP_014706142.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
Q7A_RS04435931835..932140+306WP_041354369.1hypothetical protein-
Q7A_RS04440932330..933082+753WP_014706132.1hypothetical protein-
Q7A_RS15165933315..933467+153WP_014706133.1hypothetical protein-
Q7A_RS04445933590..934501+912WP_014706134.1hypothetical protein-
Q7A_RS04450934642..934875+234WP_014706135.1hypothetical protein-
Q7A_RS04455934862..935128+267WP_041354373.1type II toxin-antitoxin system RelE/ParE family toxin-
Q7A_RS04460935165..935380+216WP_041354375.1TIGR02450 family Trp-rich protein-
Q7A_RS04465935445..935783+339WP_014706136.1thioredoxin family protein-
Q7A_RS04470936006..936230+225WP_202971552.1type II toxin-antitoxin system RelE/ParE family toxinToxin
Q7A_RS04475936220..936510+291WP_202971553.1helix-turn-helix domain-containing proteinAntitoxin
Q7A_RS04480936552..937397-846WP_014706139.1DNA ligase-
Q7A_RS04485937800..938138+339WP_014706140.1thioredoxin family protein-
Q7A_RS04490938200..938454-255WP_014706141.1Txe/YoeB family addiction module toxin-
Q7A_RS04495938451..938702-252WP_014706142.1type II toxin-antitoxin system prevent-host-death family antitoxin-
Q7A_RS04500939110..940957+1848WP_014706143.1lytic transglycosylase domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-65)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-79)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8232.48 Da        Isoelectric Point: 11.0521

>T27750 WP_202971552.1 NC_017857:936006-936230 [Methylophaga nitratireducenticrescens]
MQGTGGIRKLRWSAQGKGKSGGVRIIYFYHNGTMPLFLLTVFGKGEKANLSKSERNQLAKFTSLLRKHYGGNDD

Download         Length: 225 bp

>T27750 NC_017857:936006-936230 [Methylophaga nitratireducenticrescens]
ATGCAGGGCACGGGTGGAATTAGGAAGTTACGATGGTCTGCCCAAGGAAAAGGTAAAAGTGGTGGGGTTCGCATTATTTA
CTTCTACCACAATGGCACGATGCCGCTGTTTTTATTAACTGTATTCGGCAAAGGTGAAAAAGCGAATCTGAGCAAGTCCG
AGCGAAATCAACTTGCAAAATTCACCAGTCTTTTACGTAAGCACTATGGTGGCAATGATGACTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10458.10 Da        Isoelectric Point: 10.5650

>AT27750 WP_202971553.1 NC_017857:936220-936510 [Methylophaga nitratireducenticrescens]
MMTNAFSSIKQGLTEAVEFSKGKSSKAVVHEFSPLDVKKIRTKVGMSQNEFASAFGISVSTLRHWERGDRTPQGPALVLL
NVVAKEPELVLRALAS

Download         Length: 291 bp

>AT27750 NC_017857:936220-936510 [Methylophaga nitratireducenticrescens]
ATGATGACTAATGCATTTTCAAGTATTAAACAGGGTTTGACTGAGGCGGTAGAGTTTTCTAAAGGCAAGTCCAGTAAAGC
CGTGGTACACGAGTTTAGCCCGCTGGATGTAAAGAAGATTCGGACTAAAGTCGGTATGTCACAAAACGAATTTGCGTCGG
CGTTCGGTATAAGTGTCAGTACTCTCCGCCACTGGGAACGTGGTGATCGTACCCCGCAAGGACCCGCTCTGGTGCTTTTG
AATGTCGTCGCCAAAGAGCCGGAACTTGTGCTTCGTGCCTTGGCATCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References