Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 936006..936510 Replicon chromosome
Accession NC_017857
Organism Methylophaga nitratireducenticrescens

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag Q7A_RS04470 Protein ID WP_202971552.1
Coordinates 936006..936230 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Q7A_RS04475 Protein ID WP_202971553.1
Coordinates 936220..936510 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Q7A_RS04435 931835..932140 + 306 WP_041354369.1 hypothetical protein -
Q7A_RS04440 932330..933082 + 753 WP_014706132.1 hypothetical protein -
Q7A_RS15165 933315..933467 + 153 WP_014706133.1 hypothetical protein -
Q7A_RS04445 933590..934501 + 912 WP_014706134.1 hypothetical protein -
Q7A_RS04450 934642..934875 + 234 WP_014706135.1 hypothetical protein -
Q7A_RS04455 934862..935128 + 267 WP_041354373.1 type II toxin-antitoxin system RelE/ParE family toxin -
Q7A_RS04460 935165..935380 + 216 WP_041354375.1 TIGR02450 family Trp-rich protein -
Q7A_RS04465 935445..935783 + 339 WP_014706136.1 thioredoxin family protein -
Q7A_RS04470 936006..936230 + 225 WP_202971552.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Q7A_RS04475 936220..936510 + 291 WP_202971553.1 helix-turn-helix domain-containing protein Antitoxin
Q7A_RS04480 936552..937397 - 846 WP_014706139.1 DNA ligase -
Q7A_RS04485 937800..938138 + 339 WP_014706140.1 thioredoxin family protein -
Q7A_RS04490 938200..938454 - 255 WP_014706141.1 Txe/YoeB family addiction module toxin -
Q7A_RS04495 938451..938702 - 252 WP_014706142.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
Q7A_RS04500 939110..940957 + 1848 WP_014706143.1 lytic transglycosylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-65)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-79)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8232.48 Da        Isoelectric Point: 11.0521

>T27750 WP_202971552.1 NC_017857:936006-936230 [Methylophaga nitratireducenticrescens]
MQGTGGIRKLRWSAQGKGKSGGVRIIYFYHNGTMPLFLLTVFGKGEKANLSKSERNQLAKFTSLLRKHYGGNDD

Download         Length: 225 bp

>T27750 NC_017857:936006-936230 [Methylophaga nitratireducenticrescens]
ATGCAGGGCACGGGTGGAATTAGGAAGTTACGATGGTCTGCCCAAGGAAAAGGTAAAAGTGGTGGGGTTCGCATTATTTA
CTTCTACCACAATGGCACGATGCCGCTGTTTTTATTAACTGTATTCGGCAAAGGTGAAAAAGCGAATCTGAGCAAGTCCG
AGCGAAATCAACTTGCAAAATTCACCAGTCTTTTACGTAAGCACTATGGTGGCAATGATGACTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10458.10 Da        Isoelectric Point: 10.5650

>AT27750 WP_202971553.1 NC_017857:936220-936510 [Methylophaga nitratireducenticrescens]
MMTNAFSSIKQGLTEAVEFSKGKSSKAVVHEFSPLDVKKIRTKVGMSQNEFASAFGISVSTLRHWERGDRTPQGPALVLL
NVVAKEPELVLRALAS

Download         Length: 291 bp

>AT27750 NC_017857:936220-936510 [Methylophaga nitratireducenticrescens]
ATGATGACTAATGCATTTTCAAGTATTAAACAGGGTTTGACTGAGGCGGTAGAGTTTTCTAAAGGCAAGTCCAGTAAAGC
CGTGGTACACGAGTTTAGCCCGCTGGATGTAAAGAAGATTCGGACTAAAGTCGGTATGTCACAAAACGAATTTGCGTCGG
CGTTCGGTATAAGTGTCAGTACTCTCCGCCACTGGGAACGTGGTGATCGTACCCCGCAAGGACCCGCTCTGGTGCTTTTG
AATGTCGTCGCCAAAGAGCCGGAACTTGTGCTTCGTGCCTTGGCATCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References