Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 610652..611451 Replicon chromosome
Accession NZ_CP122648
Organism Escherichia coli strain ETEC4077

Toxin (Protein)


Gene name yhaV Uniprot ID A0A3A6SBL4
Locus tag QDY56_RS02940 Protein ID WP_062875446.1
Coordinates 610652..611116 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDY56_RS02945 Protein ID WP_001307405.1
Coordinates 611116..611451 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY56_RS02910 (605653) 605653..606087 - 435 WP_063086247.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDY56_RS02915 (606105) 606105..606983 - 879 WP_192297513.1 PTS N-acetylgalactosamine transporter subunit IID -
QDY56_RS02920 (606973) 606973..607752 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDY56_RS02925 (607763) 607763..608236 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDY56_RS02930 (608259) 608259..609539 - 1281 WP_063086249.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDY56_RS02935 (609788) 609788..610597 + 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
QDY56_RS02940 (610652) 610652..611116 - 465 WP_062875446.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDY56_RS02945 (611116) 611116..611451 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDY56_RS02950 (611600) 611600..613171 - 1572 WP_001273756.1 galactarate dehydratase -
QDY56_RS02955 (613546) 613546..614880 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QDY56_RS02960 (614896) 614896..615671 + 776 Protein_578 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17844.22 Da        Isoelectric Point: 9.4942

>T277499 WP_062875446.1 NZ_CP122648:c611116-610652 [Escherichia coli]
MDFPQRVNSWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETD

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277499 WP_001307405.1 NZ_CP122648:c611451-611116 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6SBL4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References