Detailed information of TA system TA277496

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2968..3394
• Replicon: plasmid unnamed1
• Accession: NZ_CP122644
• Organism: Escherichia coli strain ETEC4079

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: QDW55_RS25645
• Protein ID: WP_001372321.1
• Coordinates: 2968..3093 (-)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	3170..3394 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QDW55_RS25630 (1)	1..510	+	510	WP_000759173.1	transglycosylase SLT domain-containing protein	-
QDW55_RS25635 (807)	807..1628	-	822	WP_001234445.1	DUF932 domain-containing protein	-
QDW55_RS25640 (1739)	1739..2035	-	297	WP_001272251.1	hypothetical protein	-
QDW55_RS25645 (2968)	2968..3093	-	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
QDW55_RS25650 (3035)	3035..3184	-	150	Protein_4	plasmid maintenance protein Mok	-
- (3172)	3172..3237	+	66	NuclAT_0	-	-
- (3172)	3172..3237	-	66	NuclAT_1	-	-
QDW55_RS25655 (3206)	3206..3385	+	180	WP_001309233.1	hypothetical protein	-
- (3170)	3170..3394	+	225	NuclAT_0	-	-
- (3170)	3170..3394	-	225	NuclAT_0	-	Antitoxin
- (3170)	3170..3394	-	225	NuclAT_0	-	Antitoxin
- (3170)	3170..3394	-	225	NuclAT_0	-	Antitoxin
- (3170)	3170..3394	-	225	NuclAT_0	-	Antitoxin
QDW55_RS25660 (3363)	3363..4125	-	763	Protein_6	plasmid SOS inhibition protein A	-
QDW55_RS25665 (4122)	4122..4556	-	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
QDW55_RS25670 (4625)	4625..6648	-	2024	Protein_8	ParB/RepB/Spo0J family partition protein	-
QDW55_RS25675 (6709)	6709..6942	-	234	WP_000006003.1	DUF905 family protein	-
QDW55_RS25680 (7000)	7000..7527	-	528	WP_000290834.1	single-stranded DNA-binding protein	-
QDW55_RS25685 (7829)	7829..8284	+	456	Protein_11	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T277496 WP_001372321.1 NZ_CP122644:c3093-2968 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

Antitoxin

Nucleotide

• Length: 225 bp

>AT277496 NZ_CP122644:c3394-3170 [Escherichia coli]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin