Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4946495..4947097 Replicon chromosome
Accession NZ_CP122643
Organism Escherichia coli strain ETEC4079

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QDW55_RS24495 Protein ID WP_000897305.1
Coordinates 4946786..4947097 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW55_RS24490 Protein ID WP_000356395.1
Coordinates 4946495..4946785 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW55_RS24455 (4942118) 4942118..4943020 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QDW55_RS24460 (4943017) 4943017..4943652 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QDW55_RS24465 (4943649) 4943649..4944578 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QDW55_RS24470 (4944760) 4944760..4945002 - 243 WP_001306649.1 protein YiiF -
QDW55_RS24475 (4945221) 4945221..4945439 - 219 WP_001295676.1 CopG family transcriptional regulator -
QDW55_RS24480 (4945858) 4945858..4946136 - 279 WP_001306650.1 hypothetical protein -
QDW55_RS24485 (4946198) 4946198..4946410 - 213 WP_000197769.1 hypothetical protein -
QDW55_RS24490 (4946495) 4946495..4946785 - 291 WP_000356395.1 NadS family protein Antitoxin
QDW55_RS24495 (4946786) 4946786..4947097 - 312 WP_000897305.1 hypothetical protein Toxin
QDW55_RS24500 (4947326) 4947326..4948234 + 909 WP_001306651.1 alpha/beta hydrolase -
QDW55_RS24505 (4948403) 4948403..4949317 - 915 WP_225102955.1 transposase -
QDW55_RS24510 (4949330) 4949330..4950217 - 888 Protein_4797 hypothetical protein -
QDW55_RS24515 (4950633) 4950633..4951574 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QDW55_RS24520 (4951619) 4951619..4952056 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T277495 WP_000897305.1 NZ_CP122643:c4947097-4946786 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT277495 WP_000356395.1 NZ_CP122643:c4946785-4946495 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References