Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1157421..1158148 Replicon chromosome
Accession NZ_CP122643
Organism Escherichia coli strain ETEC4079

Toxin (Protein)


Gene name higB Uniprot ID V0YLE2
Locus tag QDW55_RS05595 Protein ID WP_000547555.1
Coordinates 1157421..1157732 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW55_RS05600 Protein ID WP_000126294.1
Coordinates 1157729..1158148 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW55_RS05570 (1153356) 1153356..1155065 + 1710 WP_063086195.1 formate hydrogenlyase subunit HycE -
QDW55_RS05575 (1155075) 1155075..1155617 + 543 WP_000493785.1 formate hydrogenlyase subunit HycF -
QDW55_RS05580 (1155617) 1155617..1156384 + 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
QDW55_RS05585 (1156381) 1156381..1156791 + 411 WP_001291921.1 formate hydrogenlyase assembly protein HycH -
QDW55_RS05590 (1156784) 1156784..1157254 + 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
QDW55_RS05595 (1157421) 1157421..1157732 + 312 WP_000547555.1 type II toxin-antitoxin system HigB family toxin Toxin
QDW55_RS05600 (1157729) 1157729..1158148 + 420 WP_000126294.1 helix-turn-helix domain-containing protein Antitoxin
QDW55_RS05605 (1158227) 1158227..1159651 - 1425 WP_063086210.1 6-phospho-beta-glucosidase AscB -
QDW55_RS05610 (1159660) 1159660..1161117 - 1458 WP_001107888.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
QDW55_RS05615 (1161377) 1161377..1162387 + 1011 WP_029130985.1 DNA-binding transcriptional regulator AscG -
QDW55_RS05620 (1162536) 1162536..1163063 + 528 WP_001078777.1 electron transport protein HydN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12439.18 Da        Isoelectric Point: 9.5146

>T277477 WP_000547555.1 NZ_CP122643:1157421-1157732 [Escherichia coli]
MHIISKAPFEECARKYPNDALALHSLYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT277477 WP_000126294.1 NZ_CP122643:1157729-1158148 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0YLE2

Antitoxin

Source ID Structure

References