Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 610648..611447 Replicon chromosome
Accession NZ_CP122643
Organism Escherichia coli strain ETEC4079

Toxin (Protein)


Gene name yhaV Uniprot ID A0A3A6SBL4
Locus tag QDW55_RS02940 Protein ID WP_062875446.1
Coordinates 610648..611112 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDW55_RS02945 Protein ID WP_001307405.1
Coordinates 611112..611447 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW55_RS02910 (605649) 605649..606083 - 435 WP_063086247.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDW55_RS02915 (606101) 606101..606979 - 879 WP_192297513.1 PTS N-acetylgalactosamine transporter subunit IID -
QDW55_RS02920 (606969) 606969..607748 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDW55_RS02925 (607759) 607759..608232 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDW55_RS02930 (608255) 608255..609535 - 1281 WP_063086249.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDW55_RS02935 (609784) 609784..610593 + 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
QDW55_RS02940 (610648) 610648..611112 - 465 WP_062875446.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDW55_RS02945 (611112) 611112..611447 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDW55_RS02950 (611596) 611596..613167 - 1572 WP_001273756.1 galactarate dehydratase -
QDW55_RS02955 (613542) 613542..614876 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QDW55_RS02960 (614892) 614892..615667 + 776 Protein_578 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 610648..621940 11292


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17844.22 Da        Isoelectric Point: 9.4942

>T277474 WP_062875446.1 NZ_CP122643:c611112-610648 [Escherichia coli]
MDFPQRVNSWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETD

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277474 WP_001307405.1 NZ_CP122643:c611447-611112 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6SBL4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References