277457

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4207552..4208093 Replicon chromosome
Accession NZ_CP122634
Organism Escherichia coli strain ETEC4085

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag QDW62_RS21250 Protein ID WP_000615976.1
Coordinates 4207815..4208093 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag QDW62_RS21245 Protein ID WP_000729704.1
Coordinates 4207552..4207812 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW62_RS21225 (4203227) 4203227..4204012 - 786 WP_000207587.1 putative lateral flagellar export/assembly protein LafU -
QDW62_RS21230 (4203984) 4203984..4205696 + 1713 Protein_4155 flagellar biosynthesis protein FlhA -
QDW62_RS21235 (4205920) 4205920..4206417 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
QDW62_RS21240 (4206593) 4206593..4207366 - 774 WP_015675129.1 C40 family peptidase -
QDW62_RS21245 (4207552) 4207552..4207812 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QDW62_RS21250 (4207815) 4207815..4208093 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QDW62_RS21255 (4208249) 4208249..4208989 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QDW62_RS21260 (4208960) 4208960..4209727 - 768 WP_000333379.1 class II glutamine amidotransferase -
QDW62_RS21265 (4209933) 4209933..4210511 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T277457 WP_000615976.1 NZ_CP122634:4207815-4208093 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT277457 WP_000729704.1 NZ_CP122634:4207552-4207812 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References