Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 2212794..2213165 | Replicon | chromosome |
| Accession | NZ_CP122634 | ||
| Organism | Escherichia coli strain ETEC4085 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | A0A839BBC2 |
| Locus tag | QDW62_RS10975 | Protein ID | WP_021500490.1 |
| Coordinates | 2212971..2213165 (-) | Length | 65 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 2212794..2212972 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QDW62_RS10935 (2208238) | 2208238..2208894 | - | 657 | WP_000011658.1 | carbon-nitrogen hydrolase family protein YobB | - |
| QDW62_RS10940 (2208996) | 2208996..2209226 | - | 231 | WP_000916763.1 | DNA polymerase III subunit theta | - |
| QDW62_RS10945 (2209365) | 2209365..2209739 | + | 375 | WP_000255065.1 | CopC domain-containing protein YobA | - |
| QDW62_RS10950 (2209743) | 2209743..2210615 | + | 873 | WP_000879297.1 | copper homeostasis membrane protein CopD | - |
| QDW62_RS10955 (2210628) | 2210628..2210969 | + | 342 | WP_000976472.1 | YebY family protein | - |
| QDW62_RS10960 (2211360) | 2211360..2212436 | - | 1077 | WP_236294958.1 | phage integrase Arm DNA-binding domain-containing protein | - |
| QDW62_RS10965 (2212402) | 2212402..2212683 | - | 282 | WP_001311878.1 | excisionase | - |
| - (2212794) | 2212794..2212972 | + | 179 | NuclAT_1 | - | Antitoxin |
| - (2212794) | 2212794..2212972 | + | 179 | NuclAT_1 | - | Antitoxin |
| - (2212794) | 2212794..2212972 | + | 179 | NuclAT_1 | - | Antitoxin |
| - (2212794) | 2212794..2212972 | + | 179 | NuclAT_1 | - | Antitoxin |
| QDW62_RS10970 (2212790) | 2212790..2212978 | - | 189 | WP_021529595.1 | DUF1187 family protein | - |
| QDW62_RS10975 (2212971) | 2212971..2213165 | - | 195 | WP_021500490.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| QDW62_RS10980 (2213229) | 2213229..2214317 | - | 1089 | WP_236294957.1 | RecT family recombinase | - |
| QDW62_RS10985 (2214332) | 2214332..2217406 | - | 3075 | WP_236294956.1 | exodeoxyribonuclease VIII | - |
| QDW62_RS10990 (2217508) | 2217508..2217782 | - | 275 | Protein_2144 | hypothetical protein | - |
| QDW62_RS10995 (2217857) | 2217857..2218027 | - | 171 | WP_001516462.1 | YdaE family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2205495..2275895 | 70400 | |
| - | inside | Genomic island | - | - | 2212402..2222323 | 9921 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7046.98 Da Isoelectric Point: 9.2886
>T277449 WP_021500490.1 NZ_CP122634:c2213165-2212971 [Escherichia coli]
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
Download Length: 195 bp
Antitoxin
Download Length: 179 bp
>AT277449 NZ_CP122634:2212794-2212972 [Escherichia coli]
GAGGGCAGAAGTTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTCCCCGA
GAGCATTTTTTCGCATTCCGATTTGGTTAACTTTGTTTTTGAGTACCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGGCAGAAGTTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTCCCCGA
GAGCATTTTTTCGCATTCCGATTTGGTTAACTTTGTTTTTGAGTACCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
